There isn't the space to do justice to the breadth of issues facing transgender people, some are around the process of gender reassignment, others are around the health needs that everyone else has but which are often ignored or put down to being transgender.
There are some fantastic organisations out there who support transgender people so I would suggest starting there:
Press for Change -
www.pfc.org.uk
The Gender Trust -
www.gendertrust.org.uk/
The FTM Network -
www.ftm.org.uk/
Transexual FAQ -
www.tsfaq.info/
Also I think this summary of essays and thoughts on Transgender Health issues but respected campaigner Christine Burns is a great place to start finding out more:
tinyurl.com/mpbby